Lupus & antiphospholipid syndrome
Renal Histopathology Associated With Kidney Failure and Mortality in Patients With Lupus Nephritis: A Long-Term Real-World Data Study
Authors' conclusion
Histologic variables of renal biopsy in LN could be regarded as prognostic indicators for kidney failure and mortality.
Study context
- Population
- Patients with lupus nephritis (LN) enrolled 2006–2019; renal pathology classified by ISN/RPS classification
- Participants
- 526 patients
- Exposure
- Presence vs absence of histologic variables on renal biopsy
- Outcome
- Kidney failure and death
Methodological detailsmultivariate Cox regression, adjusted for potential confounders
- Multivariate Cox regression
- Adjusted for potential confounders
Main finding
As reported in the abstract
Kidney failure (multivariate Cox regression) · median follow-up 7.5 years (IQR 3.5-10.7)
Tubular atrophy predicted kidney failure, HR
2.28 (1.66-3.14) (95% CI)
Tubulointerstitial inflammation predicted kidney failure, HR
3.13 (1.34-7.33) (95% CI)
10-year kidney survival rate where tubular atrophy and tubulointerstitial inflammation coexisted
63.22%
Patients progressed to kidney failure
58
Observational data: associations, not effects.
Further findings
Death (multivariate Cox regression) · median follow-up 7.5 years (IQR 3.5-10.7)
- Cellular crescents and death in male patients, HR
- 1.91 (1.02-3.57) (95% CI)
- Fibrous crescents and death in female patients, HR
- 5.70 (1.61-20.25) (95% CI)
- Patients died
- 64
Original publication
Renal Histopathology Associated With Kidney Failure and Mortality in Patients With Lupus Nephritis: A Long-Term Real-World Data Study. J Rheumatol. Published 1 April 2023. doi:10.
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