Lupus & antiphospholipid syndrome
Triple positive profile in antiphospholipid syndrome: prognosis, relapse and management from a retrospective multicentre study
Main finding · Relapse (new thrombotic and/or adverse obstetrical event)Result — go to the resultHazard ratio 1.63 95% CI 1.04–2.55Authors' conclusion
The triple-positivity is associated with a higher risk of relapse and obstetrical complications.
Study context
- Population
- Patients with primary or secondary antiphospholipid syndrome (APS) meeting the Sydney criteria with at least one thrombotic and/or obstetrical complication122 (59.8%) primary APS
- Participants
- 204 patients
- Exposure
- Triple-positive vs non-triple-positive APS
- Triple-positiven = 68
- Single or double positiven = 136reference
- Outcome
- Relapse (new thrombotic event and/or new adverse obstetrical event)
Methodological detailsmulticentre, multivariate analysis
- Multicentre
- Multivariate analysis
Main finding
As reported in the abstract
Relapse (new thrombotic and/or adverse obstetrical event)
Hazard ratio
1.63
95% CI 1.04–2.55
P = 0.031
By group
Triple-positive
63.2%
Triple-positivevs Non-triple-positive
HR 1.63 (95% CI 1.04–2.55); P = 0.031
Observational data: associations, not effects.
Further findings
Obstetrical APS
P = 0.010
Placental complications
P = 0.001
Non-criteria events
P = 0.002
Sneddon syndrome
P = 0.028
- Obstetrical APS: 67 patients (32.8%) overall
Thrombotic APS
- No difference between triple-positive and others (170 patients [83.3%] overall)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Triple positive profile in antiphospholipid syndrome: prognosis, relapse and management from a retrospective multicentre study. RMD Open. Published 31 March 2023. doi:10.
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