Remission definitions guiding immunosuppressive therapy in rheumatoid arthritis: which is best fitted for the purpose?
Authors' conclusion
3VBoolean definition provided the most accurate prediction of GRO and GFO, avoiding the risk of overtreatment in a substantial proportion of patients without increment in radiographic damage progression, supporting the proposal that 3VBoolean remission is preferable to guide immunosuppressive treatment.
Study context
- Population
- Patients with RA in randomised controlled trials (RCTs)
- Participants
- 4,423 patients8 RCTs
- Comparison
- Six remission definitions (Boolean, Simplified Disease Activity Index (SDAI), Clinical Disease Activity Index (CDAI), Updated-Boolean, Boolean-PhGA, 3VBoolean) as predictors of good radiographic and functional outcome
- Outcome
- Prediction of GRO (radiographic score worsening ≤0.5 units) and GFO (∆HAQ-DI≤0.0 units) during the second year by remission at 6 and/or 12 months
- Follow-up
- Second year
Pooled result
As reported in the abstract
Predictive accuracy for GRO
Further pooled results
| Outcome | Values |
|---|---|
| Proportion of GFO correctly predicted · second year | 3VBoolean 50.3% · Boolean 43.8% |
| Remission achieved (all patients) | Boolean 24% · SDAI 27% · CDAI 28% · Updated-Boolean 32% · Boolean-PhGA 33% · 3VBoolean 43% |
- Proportion of good functional outcome (GFO) correctly predicted: highest for 3VBoolean, lowest for Boolean
Proportion of GFO correctly predicted · second year
- RR of GFO ranged from 1.16 (Boolean) to 1.05 (3VBoolean)
Original publication
Remission definitions guiding immunosuppressive therapy in rheumatoid arthritis: which is best fitted for the purpose? RMD Open. Published 4 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →