American College of Rheumatology/EULAR remission criteria for rheumatoid arthritis: 2022 revision
Authors' conclusion
Using the Boolean 2.0 criteria classifies, more patients as achieving remission and increases the agreement with index-based remission criteria without jeopardising predictive value for radiographic or functional outcomes.
Study context
- Population
- Participants with early or established rheumatoid arthritis (RA) in four randomised trials comparing bDMARDs with MTX or placebo1,101 early RA, 947 established RA
- Participants
- 2,048 participants
- Comparison
- Boolean remission criteria with patient global assessment (PtGA) threshold 2 cm (Boolean2.0) vs original 1 cm threshold (Boolean1.0); agreement with Simplified Disease Activity Index (SDAI) and Clinical Disease Activity Index (CDAI) remission criteria
- Outcome
- Proportion in remission, agreement between Boolean and index-based remission criteria, and prediction of good physical function (HAQ ≤0.5) and radiographic non-progression
- Follow-up
- 6 months
Methodological detailssecondary analysis of four randomised trials, external validation, pooled data from four randomised trials
- Secondary analysis of four randomised trials
- External validation
- Pooled data from four randomised trials
Performance
As reported in the abstract
Proportion in remission · 6 months after treatment initiation
Proportion in remission · 6 months after treatment initiation
Established RA
Further findings
Prediction of radiographic non-progression and Health Assessment Questionnaire (HAQ) ≤0.5
- Boolean2.0, SDAI and CDAI remission had similar positive likelihood ratios (LRs)
- 3.8-4.3
- Omission of PtGA (BooleanX) worsened prediction of good functional outcomes
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
American College of Rheumatology/EULAR remission criteria for rheumatoid arthritis: 2022 revision. Ann Rheum Dis. Published 24 October 2022. doi:10.
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