Tenderness and radiographic progression in rheumatoid arthritis and psoriatic arthritis
Authors' conclusion
Our findings imply that tenderness in non-swollen joints in RA is associated with subsequent damage. In both diseases, additional risk factors, such as sonographic signs for synovitis and baseline radiographic damage are associated with radiographic progression.
Study context
- Population
- Patients with rheumatoid arthritis (RA) and psoriatic arthritis (PsA); clinical and sonographic (grey scale and power Doppler (PD)) examination of 22 hand joints; non-swollen joints analysed1,207 RA joints
- Participants
- 55 vs 18
- Exposure
- Tender vs non-tender non-swollen joints
- RAn = 55
- PsAn = 18
- Outcome
- Radiographic progression in non-swollen joints, by tenderness
- Follow-up
- 2 years
Methodological detailsmultilevel mixed logistic regression, joint-level analysis
- Multilevel mixed logistic regression
- Joint-level analysis
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
RAtenderness, model 2
1.85(1.01–3.27)
P = 0.047PsAtenderness; not significant
1.72(0.71–4.17)
P = 0.23Observational data: associations, not effects.
Further findings
PD and radiographic progression in non-swollen joints · 2 years
| OR (95% CI) | P value | ||
|---|---|---|---|
| RAMultilevel mixed logistic regression | 2.92 (1.71–5.00) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
Erosions and radiographic progression in non-swollen joints · 2 years
| OR (95% CI) | P value | ||
|---|---|---|---|
| RAMultilevel mixed logistic regression | 4.74 (2.44–9.23) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Tenderness and radiographic progression in rheumatoid arthritis and psoriatic arthritis. Ann Rheum Dis. Published 19 October 2022. doi:10.
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