Rheumatoid arthritis

Microvascular imaging is superior to power doppler in synovitis vascular flow detection in rheumatoid arthritis using the OMERACT-EULAR scoring system

Arthritis Res TherPublished Cross-sectional study

Authors' conclusion

In RA patients, our study demonstrates that SMI has a higher sensitivity for detecting synovial vascular flow than PD across all grades.

Study context

Population
Consecutive patients with rheumatoid arthritis (RA) fulfilling EULAR-ACR classification criteria with ultrasonographic synovitis in at least one joint; Metacarpophalangeal (MCP), proximal interphalangeal (PIP) and wrist joints (22 per patient)1,276 joints scanned
Participants
58 patients
Exposure
Superb Microvascular Imaging (SMI) vs Power Doppler (PD) for synovitis vascular flow detection in hand and wrist joints
Outcome
Detection of intra-articular vascularization in GS grade ≥ 1 joints
Methodological detailsconsecutive patients, blinded interrater agreement exercise, Interrater agreement between two ultrasonographers: squared-weighted κ = 0.729 (substantial)
  • Consecutive patients
  • Blinded interrater agreement exercise
  • Interrater agreement between two ultrasonographers: squared-weighted κ = 0.729 (substantial)

Main finding

As reported in the abstract

Intra-articular vascularization detected in GS grade ≥ 1 joints (n=227)

P < 0.001, Chi-square test

Observational data: associations, not effects.

Further findings

Outcomeχ² (9)P value
Vascular flow grading, SMI vs PDCramer's V = 0.52 (large effect size)1020.35P = 0.001
Adapted (GS + SMI) vs original (GS + PD) EULAR-OMERACT scoreCramér's V = 0.86 (large effect size)2076.09P = 0.001
Vascular flow grading, SMI vs PD — PD grade 0 increased to SMI grade ≥ 1 (joints)
79 (57.7%)
Vascular flow grading, SMI vs PD — PD grade 1 increased to SMI grade ≥ 2 (joints)
29 (74.4%)
Vascular flow grading, SMI vs PD — PD grade 2 increased to SMI grade 3 (joints)
9 (52.9%)

Vascular flow grading, SMI vs PD

No joint had higher PD grade than corresponding SMI grade

Adapted (grey-scale (GS) + SMI) vs original (GS + PD) EULAR-OMERACT score

No joint had a lower adapted EULAR-OMERACT score compared to the original

Original publication

Microvascular imaging is superior to power doppler in synovitis vascular flow detection in rheumatoid arthritis using the OMERACT-EULAR scoring system. Arthritis Res Ther. Published 10 January 2026. doi:10.1186/s13075-025-03706-5

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