Spondyloarthritis & psoriatic arthritis
Relationships of Work Productivity and Activity Impairment With Patient‐Reported Outcomes in Ankylosing Spondylitis: Results From Two Trials
Authors' conclusion
Evidence of linear relationships between work productivity and activity impairment with patient-reported pain, disease activity, and HRQoL was observed.
Study context
- Population
- Patients with active ankylosing spondylitis (AS) in phase 2 and 3 placebo-controlled tofacitinib trials330 to 475 patients, depending on analysis
- Outcome
- Relationships between WPAI:SpA domains (absenteeism, activity impairment, presenteeism, productivity loss) as outcomes and key PROs (total back pain, nocturnal spinal pain, PGA of disease activity, AS Quality of Life, EQ-5D-3L, EQ-5D-VAS) as predictors
- Follow-up
- Baseline to end of the double-blind phase
Methodological detailspooled data, placebo-controlled, double-blind phase, repeated-measures longitudinal model
- Pooled data
- Placebo-controlled
- Double-blind phase
- Repeated-measures longitudinal model
Pooled result
As reported in the abstract
Relationships between WPAI:SpA domains and PROs
Worst PRO scores associated with decline in work capacity (activity impairment, presenteeism, productivity loss)
>65%
Best PRO scores associated with improvements in WPAI:SpA domains
8%-23%
Original publication
Relationships of Work Productivity and Activity Impairment With Patient‐Reported Outcomes in Ankylosing Spondylitis: Results From Two Trials. Arthritis Care Res (Hoboken). Published 5 January 2024. doi:10.
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