Lupus & antiphospholipid syndrome
Relationship between the EULAR/ACR classification criteria and organ damage in systemic lupus erythematosus
Authors' conclusion
In addition to disease classification, the EULAR/ACR SLE criteria may have value in predicting prognosis.
Study context
- Population
- Patients judged clinical systemic lupus erythematosus (SLE) by a panel of rheumatologists, from a cross-sectional validation study of the EULAR/ACR criteria (93.6% women; age 36.5 ± 14.1 years)542 fulfilled EULAR/ACR criteria
- Participants
- 562 patients
- Exposure
- EULAR/ACR criteria score ≥20 vs 10-19
- Group 1n = 392
- Group 2n = 150reference
- Outcome
- Last SLE International Collaborating Clinic (SLICC) Organ Damage Index (SDI), compared between groups
- Follow-up
- Last clinic visit
Methodological detailsSpearman's rank correlation
- Spearman's rank correlation
Main finding
As reported in the abstract
SDI domain scores
- Group 1 had significantly higher SDI scores in the renal, cardiovascular, dermatological, and gonadal domains than group 2
Observational data: associations, not effects.
Further findings
Organ damage (SDI score ≥1), all patients
- Organ damage (SDI ≥1)
- 232 (42.8%)
EULAR/ACR criteria score in those fulfilling criteria (N = 542)
- Mean score
- 24.6 ± 7.3
- Median score (IQR 19-30)
- 24
Correlation of EULAR/ACR renal domain with renal damage
- Rho
- 0.30
- P
- P < 0.001
- Strongest correlation
Correlation of EULAR/ACR domains with total SDI
- Renal, neuropsychiatric, and antiphospholipid antibody domain scores correlated positively with total SDI
Renal and gonadal damage by renal domain points
- 10 points in renal domain had significantly higher renal damage score than 8 or 4 points
- Gonadal damage significantly more common in the 10-point than the 8-point group
Clinical and serological features
- Group 1 had significantly higher prevalence of fever, alopecia, oral ulcers, acute lupus skin lesions, arthritis, serositis, seizure, hemolytic anemia, leukopenia, renal disease, anti-dsDNA, anti-Sm, antiphospholipid antibodies and low complement
Original publication
Relationship between the EULAR/ACR classification criteria and organ damage in systemic lupus erythematosus. Lupus. Published 18 January 2023. doi:10.
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