Lupus & antiphospholipid syndrome
Longitudinal assessment of disease burden in juvenile systemic lupus erythematosus: A multicenter study of activity and damage scores
Authors' conclusion
Persistent disease activity and delayed control are major contributors to organ damage in jSLE.
Study context
- Population
- Patients with juvenile SLE followed for at least 12 months; median age at diagnosis 13.8 years; 86.7% female
- Participants
- 158 patients17 centres
- Exposure
- Patients with damage vs without damage
- Damagen = 23
- Outcome
- Risk factors associated with damage occurrence
Methodological detailsmulticentre, 17 centres
- Multicentre
- 17 centres
Main finding
As reported in the abstract
Organ damage at diagnosis (patients)
14
Organ damage at final visit (patients)
23
Proteinuria
3.2%
Cognitive dysfunction
3.2%
Observational data: associations, not effects.
Original publication
Longitudinal assessment of disease burden in juvenile systemic lupus erythematosus: A multicenter study of activity and damage scores. Lupus. Published 29 September 2025. doi:10.
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