Lupus & antiphospholipid syndrome
Clinical characteristics and treatment response of patients with SLE complicated with thrombotic thrombocytopenic purpura
Authors' conclusion
RTX-containing induction regimens resulted in high rates of clinical remission in patients with SLE-TTP. RMT was associated with a significantly reduced risk of TTP relapse and superior long-term control of SLE disease activity, without an excess risk of severe infection.
Study context
- Population
- Patients with SLE complicated with thrombotic thrombocytopenic purpura (SLE-TTP) in an SLE cohort, all given rituximab (RTX)-containing induction in the acute phase31 entered maintenance
- Participants
- 33 patients
- Exposure
- RTX maintenance therapy (RMT) vs non-RMT maintenance regimens after RTX-containing induction
- RMTn = 14
- non-RMTn = 17reference
- Outcome
- TTP relapse
- Follow-up
- Median 22.9 months
Main finding
As reported in the abstract
Log-rank p=0.027
Observational data: associations, not effects.
Further findings
| Outcome | RMT | non-RMT |
|---|---|---|
| LLDAS achieved | All patients | 59% |
Clinical remission after RTX-containing induction (all patients) · acute phase
- Clinical remission, 31/33
- 94%
Deaths during acute phase
- Deaths
- 2
Safety
- Infection rates comparable between the two groups
Original publication
Clinical characteristics and treatment response of patients with SLE complicated with thrombotic thrombocytopenic purpura. Lupus Sci Med. Published 29 September 2025. doi:10.
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