Lupus & antiphospholipid syndrome
Analysis of the serum 25(OH)D3 level and its correlation with immunological indexes in patients with systemic lupus erythematosus
Authors' conclusion
25(OH)D3 is typically insufficient in patients with SLE. Deficiency of 25(OH)D3 impacts the immune system of patients with SLE; such as lupus nephritis, anemia, and arthritis signify an elevated risk of vitamin D deficiency
Study context
- Population
- Newly diagnosed Systemic lupus erythematosus (SLE) patients admitted to a Rheumatology and Immunology Department, January 2022 to January 2024newly diagnosed SLE
- Participants
- 158 participants
- Exposure
- 25D3-deficient vs insufficient vs sufficient SLE patients
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Higher incidence of LN, anemia and arthritis, and higher anti-Sm positive rate, in 25(OH)D3-deficient vs insufficient and sufficient groups
- 25(OH)D3 positively correlated with C3, negatively with IgG and CD8+ T cells in SLE
Observational data: associations, not effects.
Further findings
IgA, IgG and CD8+ T lymphocytes, SLE vs healthy controls
- Higher in SLE than in healthy controls
Original publication
Analysis of the serum 25(OH)D3 level and its correlation with immunological indexes in patients with systemic lupus erythematosus. Lupus. Published 26 September 2025. doi:10.
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