Lupus & antiphospholipid syndrome
Development and initial content validation of a new version of the damage index in thrombotic antiphospholipid syndrome (DIAPSV2)
Authors' conclusion
A collaborative and multidisciplinary consensus-based approach developed a new version of the damage index, comprising 11 domains and 32 items (an update from 10 domains and 38 items in the original version).
Study context
- Population
- Expert panelists from different working groups; instrument for chronic damage in thrombotic APS
- Outcome
- Content validation of a new version of the damage index for thrombotic APS (DIAPSv2)
Methodological detailsmodified Delphi panel with systematic scoping review, two stages, three rounds, multidisciplinary, Item definitions updated per specialists' input and international recommendations for each domain
- Modified Delphi panel with systematic scoping review
- Two stages
- Three rounds
- Multidisciplinary
- Item definitions updated per specialists' input and international recommendations for each domain
Recommendations
As reported in the abstract
Items selected for DIAPSv2
Consensus to evaluate items of the 67 the leading committee proposed
41
Items in final consensus
32
Domains in DIAPSv2 (vs 10 domains and 38 items in original DIAPS)
11
Further findings
Stage 1 scoping review of DIAPS studies
- Evidence supported validity of original DIAPS but missing chronic-damage conditions, e.g. alveolar hemorrhage and significant bleeding due to anticoagulation therapy
Original publication
Development and initial content validation of a new version of the damage index in thrombotic antiphospholipid syndrome (DIAPSV2). Lupus. Published 24 September 2025. doi:10.
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