Lupus & antiphospholipid syndrome
Anti-neutrophil extracellular trap antibodies in autoimmune rheumatic diseases: a suitable biomarker of thrombosis in systemic lupus erythematosus
Authors' conclusion
In SLE patients, anti-NETs could have a role as a biomarker of thrombosis, a major cause of mortality in SLE.
Study context
- Population
- Patients with autoimmune rheumatic diseases (systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc)) and healthy donorspatients with autoimmune rheumatic diseases (ARD)
- Participants
- 349 patients
- Comparison
- Anti-NET antibodies in SLE, RA and SSc vs healthy donors
- SLEn = 136
- RAn = 131
- SScn = 82
- Outcome
- Prevalence of anti-NET IgG antibodies and their role as biomarker
Methodological detailshome-made ELISA (phorbol myristate acetate (PMA)-induced NET), positivity threshold at 99th percentile of healthy donors (HD) sera
- Home-made ELISA (PMA-induced NET)
- Positivity threshold at 99th percentile of HD sera
Main finding
As reported in the abstract
Anti-NET positivity (prevalence)
Observational data: associations, not effects.
Further findings
SLE: association of anti-neutrophil extracellular trap (anti-NETs) with APS
| OR (95% CI) | P value | ||
|---|---|---|---|
| Anti-NETs positive | 3.37 (1.22–9.36) | P = 0.02 | |
| 0.10.31310Odds ratio (log scale) |
SLE: association of anti-NETs with arterial thrombosis regardless of coexisting APS
| OR (95% CI) | P value | ||
|---|---|---|---|
| Anti-NETs positive | 5.52 (1.07–28.52) | P = 0.032 | |
| 0.050.21520Odds ratio (log scale) |
RA: association of anti-NETs with presence of ACPA
- Significant association between anti-NET positivity and ACPA
- P = 0.049
SSc: correlation of anti-NETs with CCL-18 (biomarker of worst prognosis and mortality in ILD-SSc)
- Direct correlation, r (CI 95% 0.04-0.50), p=0.02
- 0.289
Original publication
Anti-neutrophil extracellular trap antibodies in autoimmune rheumatic diseases: a suitable biomarker of thrombosis in systemic lupus erythematosus. Clin Exp Rheumatol. Published 23 September 2025. doi:10.
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