Lupus & antiphospholipid syndrome
Genetics of osteonecrosis in children and adults with systemic lupus erythematosus
Authors' conclusion
We identified an intronic WIPF1 variant associated with a 3.2 times increased hazard for ON (95% CI: 2.2, 4.8; P = 1.0 × 10-8) during SLE follow-up, independent of corticosteroid exposure.
Study context
- Population
- People with SLE (childhood-onset and adult-onset) from two tertiary care centres, genotyped on a multiethnic array56% cSLE
- Participants
- 940 people
- Outcome
- Symptomatic osteonecrosis (ON) confirmed by imaging
Methodological detailsmeta-GWAS of cSLE and aSLE, time-to-ON and logistic regression, two tertiary care centres, inverse-variance weighting, Median follow-up 8.0 years (IQR: 4.2, 15.7)
- meta-GWAS of cSLE and aSLE
- time-to-ON and logistic regression
- Two tertiary care centres
- Inverse-variance weighting
- Median follow-up 8.0 years (IQR: 4.2, 15.7)
Main finding
As reported in the abstract
Time-to-ON, Chr.2 SNP rs34118383 (MAF 0.18), intronic to WIPF1
HR for osteonecrosis (ON), rs34118383 (WIPF1)
3.2
95% CI 2.2, 4.8P = 1.0 × 10-8
Further findings
ON prevalence
- ON present
- 7.6% (n = 71)
Effect of SNP on time-to-ON in cSLE vs aSLE
- Similar in cSLE and aSLE
Original publication
Genetics of osteonecrosis in children and adults with systemic lupus erythematosus. Rheumatology (Oxford). Published 18 January 2023. doi:10.
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