Vasculitis & polymyalgia rheumatica
Relapse in patients with antineutrophil cytoplasmic antibody-associated vasculitis undergoing dialysis: a single-centre retrospective study in South Korea
Authors' conclusion
In patients with AAV undergoing dialysis, DAH and mean corticosteroid dose were significantly associated with relapse
Study context
- Population
- Patients with antibody-associated vasculitis (AAV) undergoing dialysis due to renal involvement, July 2005 to March 2021, single tertiary centre in Seoul, Korea (median age 64.0 years; 73.7% female; 92.1% microscopic polyangiitis (MPA))
- Participants
- 38 patients
- Exposure
- Relapse vs non-relapse; factors associated with relapse
- Relapsen = 12
- Outcome
- Factors associated with relapse
Methodological detailssingle-centre, Cox regression
- Single-centre
- Cox regression
Main finding
As reported in the abstract
Relapse-associated factors (multivariable Cox)
Adjusted hazard ratio (95% CI)P value
DAH
5.509(1.569–19.339)
P = 0.008Mean corticosteroid dose
1.381(1.161–1.642)
P < 0.001Observational data: associations, not effects.
Further findings
Relapse manifestations · During follow-up
- Relapses with diffuse alveolar haemorrhage (DAH)
- 9
- Relapses with aggravated ILD
- 2
- Relapse with DAH accompanied with neuropathy
- 1
Clinical features (age, sex, baseline Birmingham vasculitis activity score (BVAS)), relapse vs non-relapse
- Did not significantly differ between the relapse and non-relapse groups
Univariable analysis
- Lung infiltration, DAH, corticosteroid pulse therapy for induction and mean corticosteroid dose significantly associated with relapse
Original publication
Relapse in patients with antineutrophil cytoplasmic antibody-associated vasculitis undergoing dialysis: a single-centre retrospective study in South Korea. Clin Exp Rheumatol. Published 9 July 2023. doi:10.
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