Vasculitis & polymyalgia rheumatica
Low Concentrations of C5a Complement Receptor Antibodies Are Linked to Disease Activity and Relapse in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis
Authors' conclusion
Low concentrations of anti-C5aR antibodies reflect disease activity and are associated with an increased risk for relapse in AAV.
Study context
- Population
- Patients with AAV (GPA or MPA), systemic lupus erythematosus (SLE) disease controls and healthy donors60-month follow-up
- Participants
- 110 / 82 / 28 / 36 / 220
- Exposure
- AAV vs SLE disease controls vs healthy donors
- AAVn = 110
- GPAn = 82
- MPAn = 28
- SLEn = 36
- Healthy donorsn = 220reference
- Outcome
- Concentrations of circulating anti-C3aR and anti-C5aR antibodies and their association with disease activity
Methodological detailsdisease controls (SLE), healthy donor controls, flow cytometry, 60-month follow-up
- Disease controls (SLE)
- Healthy donor controls
- Flow cytometry
- 60-month follow-up
Main finding
As reported in the abstract
- In remission, anti-C3aR antibody concentrations rose to values comparable to healthy donors, whereas anti-C5aR antibody concentrations did not
- AAV vs Healthy donors: P = 0.0026
- AAV vs Healthy donors: P ≤ 0.0001
Observational data: associations, not effects.
Further findings
Relapse with low anti-C5aR antibodies · 60 months follow-up
| HR | P value | |
|---|---|---|
| GPA, low anti-C5aR | 3.54 | P = 0.0009 |
| MPA, low anti-C5aR | 4.41 | P = 0.0041 |
Correlation of anti-C5a and anti-C5aR antibody concentrations in GPA
- Inverse correlation (r)
- −0.6831
- P
- P = 0.0127
Disease activity in newly diagnosed GPA: decreased anti-C5aR (not anti-C3aR) antibodies associated
- Association of decreased anti-C5aR antibodies with disease activity
- P = 0.0009
Frequency of C5aR-expressing T cells increased in GPA, not in MPA
- CD4+ T cells, GPA
- P = 0.0021
- CD8+ T cells, GPA
- P = 0.0118
Original publication
Low Concentrations of C5a Complement Receptor Antibodies Are Linked to Disease Activity and Relapse in Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis. Arthritis Rheumatol. Published 22 February 2023. doi:10.
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