Lupus & antiphospholipid syndrome
Pulmonary involvement: A potential independent factor for quality of life in systemic lupus erythematosus
Authors' conclusion
Lupus QoL is negatively correlated with different SLE clinical parameters particularly pulmonary manifestations. Neuropsychiatric, pulmonary, renal affection, and SLEDAI are the best determinants for worse Lupus QoL.
Study context
- Population
- Systemic lupus erythematosus (SLE) patients fulfilling the 2012 Systemic Lupus International Collaborating Clinics (SLICC) criteria
- Participants
- 60 patients
- Outcome
- Quality of life (Lupus QoL) and its correlation with disease aspects, particularly pulmonary manifestations, and predictors of worse QoL
Main finding
As reported in the abstract
Correlations of Lupus QoL with disease parameters
- Lupus QoL vs PFT FEV1, FVC, DLCO (strong correlations), r
- 0.79, 0.78, 0.76, p < .001
- Lupus QoL vs mMRC dyspnea scale and HRCT score (strong negative correlations), r
- −0.96, −0.85, p < .001
- Lupus QoL vs NPSLE (moderate negative correlation), r
- −0.61, p < .001
- Lupus QoL vs photosensitivity, alopecia, Raynaud's, renal affection (weak negative correlations), r
- −0.29, −0.30, −0.30, 0.38, p = .03, .02, .02, .002
- NPSLE and pulmonary involvement: most consistent predictors of low health related quality of life (HRQoL), % variance of Lupus QoL
- 36% and 18%
Observational data: associations, not effects.
Original publication
Pulmonary involvement: A potential independent factor for quality of life in systemic lupus erythematosus. Lupus. Published 2 December 2022. doi:10.
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