A preoperative package of care for osteoarthritis, consisting of weight loss, orthotics, rehabilitation, and topical and oral analgesia (OPPORTUNITY): a two-centre, open-label, randomised controlled feasibility trial
An erratum to this article was published (Lancet Rheumatol, Feb 2026 ↗)
Authors' conclusion
Participants adhered well to the non-operative interventions and their health-related quality of life improved.
Study context
- Population
- Patients aged 15–85 years on the waiting list for knee arthroplasty for OA, meeting at least one threshold for an intervention component; two secondary care centres, UK233 screened
- Participants
- 60 patients
- Comparison
- Preoperative package of non-operative care (weight loss, exercise therapy, insoles, analgesia adjustment) delivered weekly over 12 weeks vs standard of care
- Primary endpoint
- Acceptability and feasibility of delivering the intervention: recruitment rate, retention at follow-up after planned surgery, health-related quality of life, joint-specific scores and adherence (weight change and qualitative interviews)
Methodological detailsopen-label, two-centre, 2:1 randomisation
- Open-label
- Two-centre
- 2:1 randomisation
Primary result
As reported in the abstract
Feasibility: recruitment, uptake and adherence
- Randomly assigned of patients screened
- 60 (27%)
- Uptake: exercise therapy (Intervention)
- 31 (78%) of 40
- Uptake: weight loss (Intervention)
- 28 (70%)
- Uptake: analgesia adjustment (Intervention)
- 22 (55%)
- Uptake: insoles (Intervention)
- 18 [45%]
- Overall median adherence
- 94% (IQR 79.5-100)
Further findings
Mean, kg
| Outcome | Intervention | Control | Estimated difference (kg) (95% CI) | |
|---|---|---|---|---|
| Weight change at final reviewValues are mean weight lost | 11.2 (SD 5.6) | 1.3 (SD 3.8) | −9.8 (−13.4 to −6.3) | |
| −20−10010Difference, kg (linear scale) |
Health-related quality of life, mean change
- Clinically significant improvement in health-related quality of life, mean change (SD)
- 0.078 [SD 0.195]
Joint-specific scores
- Greater improvement in the intervention group than in the control group
Safety
Adverse events attributable to the intervention
- None occurred
- 0
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
A preoperative package of care for osteoarthritis, consisting of weight loss, orthotics, rehabilitation, and topical and oral analgesia (OPPORTUNITY): a two-centre, open-label, randomised controlled feasibility trial. Lancet Rheumatol. Published 26 February 2024. doi:10.
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