Autoinflammatory & rare systemic diseases
Predictors and prognosis of tracheostomy in relapsing polychondritis
Authors' conclusion
Tracheostomy is associated with an increase in the short-term mortality rate but does not affect the long-term survival rate.
Study context
- Population
- Patients with relapsing polychondritis (146 with laryngeal involvement)146 with laryngeal involvement
- Participants
- 232 patients
- Exposure
- Relapsing polychondritis with vs without tracheostomy
- Tracheostomyn = 21
- Outcome
- Risk factors for tracheostomy
Methodological detailsmultivariate logistic regression, nomogram risk prediction model, internal bootstrap validation (1000 repetitions), decision curve analysis
- Multivariate logistic regression
- Nomogram risk prediction model
- Internal bootstrap validation (1000 repetitions)
- Decision curve analysis
Main finding
As reported in the abstract
Independent risk factors for tracheostomy (multivariate logistic analysis)
- Age ≤25 or ≥65 years: OR 24.584 (95% CI 5.310-113.815)
- P < 0.001
- Laryngotracheal oedema: OR 26.685 (95% CI 4.208-169.228)
- P < 0.001
- Pulmonary infection: OR 18.834 (95% CI 3.172-111.936)
- P = 0.001
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| In-hospital mortalitySignificant increase with tracheostomy | P = 0.021 |
| Long-term survivalNot affected by tracheostomy | P = 0.706 |
Nomogram discrimination
- C-index
- 0.936 (95% CI 0.894-0.977)
- C-index, internal bootstrap resampling (1000 repetitions)
- 0.926
- Decision curve analysis indicated a superior net benefit of the nomogram
Original publication
Predictors and prognosis of tracheostomy in relapsing polychondritis. Rheumatology (Oxford). Published 2 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →