Autoinflammatory & rare systemic diseases
Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19
Authors' conclusion
In this retrospective cohort study, COVID-19 was associated with a substantial risk for autoimmune and autoinflammatory connective tissue disorders
Study context
- Population
- Nationwide Korean data (KDCA COVID-19 NHIS cohort), October 8, 2020 to December 31, 202132 covariates balanced by IPW
- Participants
- 354,527 vs 6,134,940
- Exposure
- COVID-19 vs controls with no evidence of COVID-19
- COVID-19n = 354,527
- Controlsn = 6,134,940reference
- Outcome
- Incidence and risk of autoimmune and autoinflammatory connective tissue disorders following COVID-19
Methodological detailspopulation-based, nationwide, inverse probability weighting, multivariable Cox proportional hazard analyses
- Population-based
- Nationwide
- Inverse probability weighting
- Multivariable Cox proportional hazard analyses
Main finding
As reported in the abstract
Risk of autoimmune and autoinflammatory connective tissue disorders
COVID-19 vs ControlsAdjusted hazard ratio (95% CI)
Alopecia areata
1.12(1.05–1.19)
Alopecia totalis
1.74(1.39–2.17)
AAV
2.76(1.64–4.65)
Crohn disease
1.68(1.31–2.15)
Sarcoidosis
1.59(1.00–2.52)
Observational data: associations, not effects.
Further findings
Association with COVID-19 severity
- Risks of alopecia totalis, psoriasis, vitiligo, vasculitis, Crohn disease, ulcerative colitis, RA, AOSD, Sjögren syndrome, AS and sarcoidosis were associated with the severity of COVID-19
Original publication
Autoimmune and Autoinflammatory Connective Tissue Disorders Following COVID-19. JAMA Netw Open. Published 2 October 2023. doi:10.
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