Autoinflammatory & rare systemic diseases
Reassessing the role of watchful waiting strategy for IgG4-related disease: a real-world study
Authors' conclusion
“Watchful waiting” strategy may not be the optimal immediate choice for patients with mild symptoms, low disease activity, and limited organ involvement, even after the surgical resection of involved organs.
Study context
- Population
- IgG4-related disease (IgG4-RD) patients asymptomatic or with low disease activity meeting watchful-waiting criteria modified from the 2015 International Consensus Guidance Statement, October 2018 to October 2022median IgG4-RD responder index (RI) 2
- Participants
- 49 participants
- Exposure
- Watchful waiting vs routine medical treatment
- WAITn = 25
- Outcome
- Cumulative recurrence rate
- Follow-up
- During (median 48 months)
Methodological detailsreal-world, single-centre
- Real-world
- Single-centre
Main finding
As reported in the abstract
during follow-up
Observational data: associations, not effects.
Further findings
Relapse within WAIT by surgical resection of involved organs (subgroup)
- All relapse events in WAIT were in patients who had undergone surgical resection of involved organs, who scored significantly higher on the 2019 ACR/EULAR classification criteria for IgG4-RD
Original publication
Reassessing the role of watchful waiting strategy for IgG4-related disease: a real-world study. Arthritis Res Ther. Published 29 January 2026. doi:10.
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