Autoinflammatory & rare systemic diseases
Outcome and risk factors for progression in IgG4-related disease under watchful waiting
Authors' conclusion
IgG4-RD patients with internal organ involvement exhibit a higher rate of disease progression under watchful waiting. Paranasal sinus involvement, high RI, high Eos%, and high IgE levels were identified as potential risk factors for disease progression.
Study context
- Population
- Immunoglobulin G4-related disease (IgG4-RD) patients managed with the watchful waiting strategy
- Participants
- 40 patients
- Exposure
- IgG4-RD without vs with internal organ involvement under watchful waiting
- WOIn = 26reference
- WIn = 14
- Outcome
- Disease progression under watchful waiting
Methodological detailslogistic and Cox regression, Kaplan-Meier analysis
- Logistic and Cox regression
- Kaplan-Meier analysis
Main finding
As reported in the abstract
Progression
WOI
5
events
WI
7
events
P = 0.048
- Progression overall
- 12/40
Observational data: associations, not effects.
Further findings
Risk factors for progression in WOI
- Paranasal sinus involvement, high response index (RI), elevated eosinophil percentage (Eos%) and high IgE levels were significant risk factors for progression
Timing of progression
- All progression events occurred within the first year of follow-up; estimated hazard function peaked at 6 to 8 months and declined thereafter
Original publication
Outcome and risk factors for progression in IgG4-related disease under watchful waiting. Clin Exp Rheumatol. Published 23 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →