Autoinflammatory & rare systemic diseases
IgG4-related prostatitis: expanding the spectrum of IgG4-related disease. A systematic review
Authors' conclusion
IgG4-related prostatitis is a rare and likely under-recognised manifestation of IgG4-RD.
Study context
- Population
- Cases of prostatic involvement in Immunoglobulin G4-related disease (IgG4-RD) (IgG4-related prostatitis) reported in English-language studies, searched from inception to 12 February 2025
- Participants
- 66 cases50 studies
- Outcome
- Clinical manifestations, diagnosis, treatment and outcomes of IgG4-related prostatitis
Methodological detailsPRISMA 2020, descriptive analysis of case reports, case series and observational studies
- PRISMA 2020
- Descriptive analysis of case reports, case series and observational studies
Pooled result
As reported in the abstract
- Age, median (range 20-82), years
- 64
- Serum IgG4, median (range 5-4,500), mg/dL; elevated in most
- 832
- Prostate-specific antigen (PSA) levels varied widely, ng/mL
- 0.01-180
- Multiorgan involvement
- 57.8%
- Isolated disease
- 6.2%
- Lower urinary tract symptoms (most frequent)
- 39.6%
- GC, mainly prednisone, as main therapy; followed by surgery, chiefly transurethral resection of the prostate
- 69.2%
- Complete response
- 50.9%
- Partial response
- 43.4%
- Treatment type correlated with outcome (χ²=49.70)
- p<0.001
- Malignancy
- 18.5%
- Malignancy associated with higher mortality
- p=0.028
Original publication
IgG4-related prostatitis: expanding the spectrum of IgG4-related disease. A systematic review. Clin Exp Rheumatol. Published 16 October 2025. doi:10.
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