Autoinflammatory & rare systemic diseases
Update on Palmar Fasciitis and Polyarthritis Syndrome: A systematic review
Authors' conclusion
PFPAS is a rare paraneoplastic condition, and early recognition of its distinctive symptoms may lead to the detection of underlying malignancy and timely treatments, potentially saving lives.
Study context
- Population
- Patients with Palmar Fasciitis and Polyarthritis Syndrome (PFPAS); Scopus, Embase and PubMed searched from inception to December 31, 2023
- Participants
- 121 patients
- Comparison
- Chemotherapies vs Operations vs Biologics
- Chemotherapiesn = 50
- Operationsn = 24
- Biologicsn = 2
- Outcome
- Clinical, laboratory and imaging characteristics of PFPAS patients, and effectiveness of different treatments
Pooled result
As reported in the abstract
Clinical characteristics of PFPAS patients
- Mean onset age
- 61.4 years
- Hand swelling or thickening
- 49.6%, n=60/121
- Hand pain
- 41.3%, n=50/121
- Median time from PFPAS symptom onset to detection of malignancy
- 4 months
- Median survival
- 13.0 months (range=2 to 69)
- Abnormal rate of musculoskeletal US, MRI and bone scan
- more than 80%
Further pooled results
| Outcome | Chemotherapies | Operations |
|---|---|---|
| Effective therapeutic response | 66.0% | 79.2% |
- Partial remission with biologics
- 2 · events
Original publication
Update on Palmar Fasciitis and Polyarthritis Syndrome: A systematic review. Joint Bone Spine. Published 18 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →