Autoinflammatory & rare systemic diseases
Joint involvement in sarcoidosis: systematic review and meta-analysis of prevalence, clinical pattern and outcome
Authors' conclusion
SA occurred early in the disease with a PPE of 19% and most frequent pattern of acute oligo- or polyarthritis predominantly affecting the lower extremity large joints.
Study context
- Population
- Sarcoidosis patients in publications reporting joint involvement (JI) prevalence, pattern, treatment and outcome (MEDLINE, EMBASE, Cochrane Library, inception to July 2022)49 articles
- Participants
- 8,574 patients
- Outcome
- Pooled prevalence estimate (PPE) of joint involvement
Methodological detailsrandom effects, binomial distribution, meta-regression
- Random effects
- Binomial distribution
- Meta-regression
Pooled result
As reported in the abstract
JI, pooled prevalence estimates (PPE)
12%
95% CI 10, 14; I2 = 0%
Sarcoid arthritis, PPE
19%
95% CI 14, 24; I2 = 95%
Arthralgia, PPE
32%
95% CI 13, 51; I2 = 99%
Further pooled results
Pattern of sarcoid arthritis
- Ankles affected, PPE (most frequent, followed by knees and wrists)
- 80%
- Monoarthritis, PPE
- 1% (95% CI 0, 2; I2 = 55%)
- Acute sarcoid arthritis (SA), PPE (95% CI 72, 88; I2 = 69%); equal proportion oligo- and polyarthritis
- 79%
- Erythema nodosum with acute SA, PPE
- 62% (95% CI 52, 71; I2 = 16%)
- Chronic SA predominantly polyarticular, more upper extremity joints
- SA sample size 12 to 117 cases
Non-articular manifestations with SA
- Fever
- 52%
- Erythema nodosum
- 41%
- Hilar adenopathy
- 86%
- ILD (one-third required corticosteroids and/or immunosuppressants)
- 23%
Original publication
Joint involvement in sarcoidosis: systematic review and meta-analysis of prevalence, clinical pattern and outcome. Rheumatology (Oxford). Published 27 January 2024. doi:10.
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