Autoinflammatory & rare systemic diseases
Increased risk of osteoporosis and femoral neck fractures in patients with familial Mediterranean fever—a large retrospective cohort study
Main finding · OsteoporosisResult — go to the resultCrude hazard ratio 1.62 95% CI 1.35–1.93Authors' conclusion
FMF patients are at increased risk for osteoporosis and consequently femur fracture.
Study context
- Population
- Familial Mediterranean fever (FMF) patients first diagnosed 2000–2016 and matched controls, Clalit Health Services electronic databasemedian follow-up 12.5 years
- Exposure
- FMF patients vs age- and sex-matched controls
- FMFn = 9,769
- Outcome
- Incidence and risk of osteoporosis and femoral neck fracture
Methodological detailsage- and sex-matched controls 1:1, univariate and multivariate Cox regression
- Age- and sex-matched controls 1:1
- Univariate and multivariate Cox regression
Main finding
Osteoporosis
Crude hazard ratio
1.62
95% CI 1.35–1.93
P < 0.001
Events by group
FMFvs Controls
crude HR 1.62 (95% CI 1.35–1.93); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
Per 10 000 persons-years
| Outcome | FMF | Controls | Crude HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Femoral neck fracture, incidence rate per 10 000 persons-years · median follow-up 12.5 years | 5.3 | 3.3 | 1.60 (1.05–2.44) | P < 0.05 | |
| 0.512Crude hazard ratio (log scale) |
- Age at osteoporosis diagnosis (FMF patients diagnosed considerably younger than controls)
- P = 0.028
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Increased risk of osteoporosis and femoral neck fractures in patients with familial Mediterranean fever—a large retrospective cohort study. Rheumatology (Oxford). Published 28 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →