Autoinflammatory & rare systemic diseases

Laryngeal involvement in relapsing polychondritis: clinical and CT findings in 173 patients

RMD OpenPublished Retrospective cohort study

Authors' conclusion

Laryngeal involvement is common in RP patients with airway manifestations, second only to tracheal involvement. CT findings of cricoid erosion and broadening are characteristic.

Study context

Population
Patients with confirmed relapsing polychondritis (RP)
Participants
173 patients
Outcome
Clinical features and CT findings of laryngeal involvement in RP

Main finding

As reported in the abstract

CT evidence of airway involvement

Asymptomatic patients with CT evidence of airway damage

66%

Laryngeal involvement

41.1%

44/107

Tracheal involvement

80.9%

140/173

Bronchial involvement

36.4%

63/107

Observational data: associations, not effects.

Further findings

Factors associated with laryngeal involvement

Younger age at disease onset
P < 0.05
Longer disease duration
P < 0.01
Multiorgan manifestations
P < 0.01

Original publication

Laryngeal involvement in relapsing polychondritis: clinical and CT findings in 173 patients. RMD Open. Published 8 May 2025. doi:10.1136/rmdopen-2024-005397

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