Autoinflammatory & rare systemic diseases
Performance Characteristics of Anti–Collagen II Antibodies in Relapsing Polychondritis and Related Diseases: Prospective Analysis, Systematic Review, and Meta‐Analysis
Authors' conclusion
Anti-Col2 antibodies are neither sensitive nor specific for RP, are detected in the minority of patients with RP, and are detected at similar prevalences across a spectrum of inflammatory diseases with cartilage inflammation.
Study context
- Population
- Patients with relapsing polychondritis (RP) and other inflammatory diseases that mimic RP; meta-analysis across a broad spectrum of diseases71 articles in review
- Comparison
- Anti-Col2 antibodies in RP vs inflammatory diseases that mimic RP
- Outcome
- Performance characteristics of anti-Col2 antibodies to diagnose RP
Methodological detailsobservational cohort, diagnostic accuracy
- Observational cohort
- Diagnostic accuracy
Pooled result
As reported in the abstract
Diagnostic performance of anti-Col2 for RP (observational cohort)
| Group | Sensitivity | Specificity |
|---|---|---|
| RP | 18% | 72% |
RP
Sensitivity18%
Specificity72%
Further pooled results
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Meta-analysis: association of anti-Col2 with RP (5 pooled studies) | 2.09 (0.05–81.80) | P = 0.69 | |
| 0.050.21520Relative risk (log scale) |
Meta-analysis: association of anti-Col2 with composite inflammatory diseases with cartilaginous involvement
| RR (95% CI) | P value | ||
|---|---|---|---|
| Inflammatory diseases with cartilaginous involvement | 2.99 (1.29–6.91) | P = 0.01 | |
| 0.10.31310Relative risk (log scale) |
Correlation of anti-Col2 titers with disease activity in RP
- R
- 0.08
- P
- P = 0.44
Effect sizes in studies using healthy vs disease controls
- β-estimate
- 1.14
- I2
- 17.08%
- P
- P = 0.0004
- Increased effect sizes with healthy controls
Original publication
Performance Characteristics of Anti–Collagen II Antibodies in Relapsing Polychondritis and Related Diseases: Prospective Analysis, Systematic Review, and Meta‐Analysis. Arthritis Care Res (Hoboken). Published 11 February 2026. doi:10.
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