Porphyromonas gingivalis associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population
Authors' conclusion
Antibodies against the oral bacterium Pg are elevated during the RA-risk phase, both in individuals progressing to arthritis and in individuals remaining arthritis-free.
Study context
- Population
- At-risk individuals positive for anti-CCP2 antibodies with musculoskeletal complaints but no signs of arthritis260 Risk-RA baseline samples
- Exposure
- Anti-Rgp IgG in anti-CCP2-positive at-risk individuals vs healthy controls; progressors vs arthritis-free
- Progressorsn = 95
- Arthritis-freen = 165reference
- Controlsn = 126reference
- Outcome
- Association of anti-Rgp IgG with the rheumatoid arthritis (RA)-risk phase and development of arthritis
Methodological detailsat-risk population, follow-up ≥3 years or until arthritis onset, Cox regression
- At-risk population
- Follow-up ≥3 years or until arthritis onset
- Cox regression
Main finding
As reported in the abstract
Anti-Rgp IgG positivity at baseline
P = 0.003
Observational data: associations, not effects.
Further findings
Development of arthritis by baseline anti-Rgp IgG
| HR (CI) | P value | ||
|---|---|---|---|
| Anti-Rgp IgG levelsCox regression | 0.95 (0.80–1.13) | P = 0.6 | |
| Anti-Rgp IgG positivityCox regression | 0.82 (0.55–1.23) | P = 0.3 | |
| 0.512Hazard ratio (log scale) |
Anti-Rgp IgG levels during follow-up
- No changes in anti-Rgp IgG levels were observed during follow-up
Original publication
Porphyromonas gingivalis associates with the presence of anti-citrullinated protein antibodies, but not with the onset of arthritis: studies in an at-risk population. RMD Open. Published 31 January 2025. doi:10.
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