Diagnostic performance of optical spectral transmission compared to magnetic resonance imaging in patients with inflammatory arthritis
Authors' conclusion
OST showed an excellent performance compared to MRI and correlated significantly with RAMRIS scores and clinical parameters in IA patients, also differentiating IA from HC.
Study context
- Population
- Patients who underwent magnetic resonance imaging (MRI) and optical spectral transmission (OST) for suspected inflammatory arthritis, with known rheumatic diseases71 patients, 114 healthy control (HC)
- Comparison
- OST vs MRI in patients with suspected inflammatory arthritis (IA); healthy controls for comparison
- MRI+n = 51
- HCn = 114reference
- Outcome
- Performance of OST in assessing joint inflammation compared to MRI (ROC)
Methodological detailshistorical healthy control group, MRI (Rheumatoid Arthritis MRI Score (RAMRIS)) as reference
- Historical healthy control group
- MRI (RAMRIS) as reference
Performance
As reported in the abstract
OST score
| Test or model | Value | AUC (wrist level, MRI as reference) |
|---|---|---|
| MRI+ | 16.41 ± 5.53 | 0.833 (95%CI 0.700-0.966) |
| MRI inflammation (MRI-) | 11.52 ± 5.03 | |
| HC | 10.78 ± 4.19 |
Value
MRI+16.41 ± 5.53
MRI inflammation (MRI-)11.52 ± 5.03
HC10.78 ± 4.19
AUC (wrist level, MRI as reference)
MRI+0.833 (95%CI 0.700-0.966)
MRI inflammation (MRI-)— not stated in the abstract
HC— not stated in the abstract
- MRI+ vs MRI-: P < 0.001 — significantly higher OST scores in MRI+
- MRI+ vs HC: P < 0.001 — significantly higher OST scores in MRI+
Further findings
Correlation of OST with RAMRIS synovitis and tenosynovitis scores (MRI+)
- RAMRIS-synovitis, rho
- 0.541, p < 0.001
- RAMRIS-tenosynovitis, rho
- 0.341, p = 0.01
Correlation of OST with clinical disease activity parameters
- Significant correlations observed
Original publication
Diagnostic performance of optical spectral transmission compared to magnetic resonance imaging in patients with inflammatory arthritis. Arthritis Res Ther. Published 30 January 2025. doi:10.
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