Clinical evaluation of optical spectral transmission imaging for detection of disease activity in rheumatoid arthritis
Authors' conclusion
OST provides an objective measure of synovitis and correlates moderately with other examined disease activity assessment tools.
Study context
- Population
- Rheumatoid arthritis (RA) patients and controls undergoing optical spectral transmission (OST) imaging
- Participants
- 24 vs 37
- Comparison
- RA patients vs controls
- RAn = 24
- Controlsn = 37reference
- Outcome
- OST score (performance of OST for measuring joint inflammation in RA)
Methodological detailscase-control
- Case-control
Performance
As reported in the abstract
OST score
RA
16.9
median · IQR 12.77–19.7
Controls
12.11
median · IQR 10.32–14.93
Further findings
| Outcome | RA |
|---|---|
| Joint-level discrimination (US or clinical swelling as reference)Range across reference standards | |
| AUC | 0.63 to 0.70 |
Association of OST score with US, patient level, RA
- Beta (95% CI 0.16-0.60), p = 0.001
- 0.38
Association of OST score with DAS28-CRP, patient level, RA
- Beta (95% CI 0.04- 0.57), p = 0.024
- 0.30
Factors associated with OST score in controls
- Male sex, high BMI and hypertension associated with higher OST scores in controls; associations absent in RA
Radiographic features and OST joint scores
- Joint-space narrowing and malalignment associated with higher OST joint scores; subchondral sclerosis with lower scores
Original publication
Clinical evaluation of optical spectral transmission imaging for detection of disease activity in rheumatoid arthritis. Scand J Rheumatol. Published 28 March 2023. doi:10.
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