Optical spectral transmission to monitor disease activity in arthritis patients: longitudinal follow-up comparison with clinical parameters
Authors' conclusion
OST was able to reliably assess disease activity and correlated longitudinally with arthritis activity markers, showing promising potential during monitoring of inflammatory arthritis.
Study context
- Population
- Patients with known rheumatic inflammatory diseases and clinical suspicion of inflammatory activity, optical spectral transmission (OST) at two time points1,312 joints of 60 patients
- Participants
- 60 vs 114
- Comparison
- OST in inflammatory arthritis vs historic healthy controls; ΔOST vs changes in clinical activity markers
- Inflammatory arthritisn = 60
- Controln = 114reference
- Outcome
- Longitudinal association of OST with clinical inflammatory arthritis activity markers (DAS28, SJC)
Methodological detailshistoric control group, ROC analysis, correlation analyses
- Historic control group
- ROC analysis
- Correlation analyses
Performance
As reported in the abstract
Longitudinal change in OST (ΔOST) vs change in clinical activity markers
ΔOST correlation with ΔDAS28 (r)
r = 0.377
P = 0.004
ΔOST correlation with ΔSJC (r)
r = 0.488
P < 0.001
Further findings
| Outcome | P value |
|---|---|
| Mean OST scores, inflammatory arthritis vs controlSignificantly higher in inflammatory arthritis | P < 0.001 |
Cross-sectional correlation of OST with DAS28, swollen joint counts (SJC) and TJC · both time points
- OST correlated significantly with DAS28, SJC and TJC
- all; P < 0.05
Diagnostic performance of OST vs historic healthy controls (baseline ROC)
- AUC
- 0.781 (95% CI 0.82-0.94)
Original publication
Optical spectral transmission to monitor disease activity in arthritis patients: longitudinal follow-up comparison with clinical parameters. Rheumatology (Oxford). Published 3 January 2025. doi:10.
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