Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (Difficult-to-Treat RA (D2T-RA)) independent of age and gender
Authors' conclusion
High disease activity, baseline erosions and disease duration are significantly associated with the D2T phenotype of RA while we confirm the importance of obesity and fibromyalgia.
Study context
- Population
- Patients consecutively seen for rheumatoid arthritis (RA) between January 2019 and January 2023
- Participants
- 458 participants
- Exposure
- D2T-RA vs non-D2T RA
- D2T-RAn = 71
- Outcome
- Clinical features associated with D2T-RA
Methodological detailsconsecutive patients, logistic regression adjusted for confounders
- Consecutive patients
- Logistic regression adjusted for confounders
Main finding
As reported in the abstract
Factors associated with D2T-RA, multivariate analysis
Each group vs non-D2TEstimate (95% CI)P value
D2T-RA
OR per disease duration 1.06(1.03–1.09)
P < 0.0001D2T-RA
OR for baseline erosions 2.73(1.28–5.82)
P = 0.009D2T-RA
OR for obesity 2.22(1.10–4.50)
P = 0.026D2T-RA
OR for FM 3.91(1.76–8.70)
P = 0.001Observational data: associations, not effects.
Further findings
Disease duration
P < 0.0001
Erosions at baseline
P < 0.0001
Obesity
P = 0.021
FM
P < 0.0001
RF positivity
ACPA positivity
| Outcome | D2T-RA | non-D2T | P value |
|---|---|---|---|
| CDAI · last follow up visit | 15.7 ± 10.5 | 7.5 ± 8.8 | P < 0.0001 |
| Age | median 62 (IQR 58–65) years | median 62 (IQR 60–63) |
Age
- No significant difference
RF positivity
- No significant difference
Anti-Citrullinated Protein Antibodies (ACPA) positivity
- No significant difference
Gender prevalence
- 23% in both groups; no significant difference
Original publication
Obesity and fibromyalgia are associated with Difficult-to-Treat Rheumatoid Arthritis (D2T-RA) independent of age and gender. Arthritis Res Ther. Published 3 January 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →