Optical spectral transmission to assess glucocorticoid therapy response in patients with arthritis: a longitudinal follow-up comparison with joint ultrasound
Authors' conclusion
OST was able to assess response to therapy in a similar way to joint US and correlated significantly with arthritis activity markers.
Study context
- Population
- Patients with active arthritis of the wrist and finger joints during a disease flare treated with oral glucocorticoids (GC)1,173 joints of 54 patients
- Participants
- 54 vs 114
- Comparison
- Optical spectral transmission (OST) vs joint ultrasonographic (US) (PDUS, GSUS) before and after oral GC during a flare; patients vs controls
- Patientsn = 54
- Controlsn = 114reference
- Outcome
- Agreement of change in OST values (ΔOST) with ΔPDUS and ΔGSUS between the two time-points (before and after GC)
- Follow-up
- Before and after oral GC
Methodological detailslongitudinal follow-up, comparison with joint US, Bayesian statistical analyses
- Longitudinal follow-up
- Comparison with joint US
- Bayesian statistical analyses
Performance
As reported in the abstract
Agreement of ΔOST with ΔPDUS and ΔGSUS (Bayesian accuracy) · before vs after GC
- Same value-change tendency of OST and US
- 83.2%
- ΔOST vs ΔPDUS, metacarpophalangeal (MCP): no significant difference (accuracy)
- 68.1%
- ΔOST vs ΔPDUS, proximal interphalangeal (PIP): no significant difference (accuracy)
- 60.4%
- ΔOST vs ΔPDUS, wrists: no significant difference (accuracy)
- 50.4%
- ΔOST vs ΔGSUS, MCP: no significant difference (accuracy)
- 51.1%
- ΔOST vs ΔGSUS, PIP: no significant difference (accuracy)
- 78.7%
Further findings
| Outcome | Patients |
|---|---|
| OST diagnostic performance, patients vs controls (AUC) · before GC | |
| AUC | 0.883 |
| 95% CI | 0.83-0.94 |
| OST diagnostic performance, patients vs controls (AUC) · after GC | |
| AUC | 0.811 |
| 95% CI | 0.74-0.881 |
- OST diagnostic performance, patients vs controls (AUC): p<0.001
- OST diagnostic performance, patients vs controls (AUC): p<0.001
Correlation of OST with activity markers
- OST correlated significantly with all examined sonographic activity scores
- P < 0.001
- OST correlated significantly with swollen joint counts
- P < 0.01
Original publication
Optical spectral transmission to assess glucocorticoid therapy response in patients with arthritis: a longitudinal follow-up comparison with joint ultrasound. Arthritis Res Ther. Published 25 March 2023. doi:10.
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