Characteristics of patients with difficult-to-treat rheumatoid arthritis in a French single-centre hospital
Authors' conclusion
Low socioeconomic status, diabetes, interstitial lung disease and absence of combination with methotrexate allow identification of D2TRA.
Study context
- Population
- Consecutive RA patients treated at Cochin Hospital, France
- Participants
- 320 consecutive RA patients
- Exposure
- Difficult-to-treat rheumatoid arthritis (D2TRA) vs non-D2TRA, by EULAR and Alternative definitions
- EULAR-D2TRAn = 76
- non-DTRA (EULAR)n = 244reference
- Alternative D2TRAn = 120
- non-DTRA (Alternative)n = 200reference
- Outcome
- Features of D2TRA vs non-D2TRA (both definitions)
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
As reported in the abstract
- Compared with non-D2TRA, D2TRA patients from both definitions more likely to have lower socioeconomic level, positive RF, ILD, higher DAS28-CRP, and more likely to respond to RTX and JAKi
- EULAR and Alternative D2TRA displayed similar clinical and biological features but different therapeutic profiles
Observational data: associations, not effects.
Further findings
| Outcome | EULAR-D2TRA | Alternative D2TRA | P value |
|---|---|---|---|
| Patients receiving MTXAlternative D2TRA vs EULAR-D2TRA | 64% | 53% | P = 0.046 |
- Patients receiving MTX: comparator of 64% not explicitly named in the abstract
Alternative D2TRA not fulfilling EULAR definition
- All had received two successive first-line TNFi (a monoclonal antibody and a soluble receptor); comparable to EULAR-D2TRA in all other characteristics
- n = 44
Original publication
Characteristics of patients with difficult-to-treat rheumatoid arthritis in a French single-centre hospital. Rheumatology (Oxford). Published 24 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →