Dynamics of the gut microbiome in individuals at risk of rheumatoid arthritis: a cross-sectional and longitudinal observational study
Authors' conclusion
These data suggest conflicting reports on Prevotellaceae overabundance are likely due to sampling within a heterogeneous population along a dynamic disease spectrum, with certain Prevotellaceae strains/clades possibly contributing to the establishment and/or progression of RA.
Study context
- Population
- Individuals at risk of rheumatoid arthritis (RA): Anticyclic citrullinated protein (anti-CCP) antibodies and new musculoskeletal symptoms without clinical synovitis19 sampled longitudinally
- Participants
- 124 individuals
- Exposure
- RA progressors vs non-progressors among anti-CCP+ individuals at risk of RA
- Progressorsn = 30
- Outcome
- Gut microbiome Prevotellaceae abundance at baseline
- Follow-up
- Baseline
Methodological details16S rRNA amplicon sequencing, shotgun metagenomic DNA sequencing confirmation
- 16S rRNA amplicon sequencing
- Shotgun metagenomic DNA sequencing confirmation
Main finding
As reported in the abstract
- CCP+ at risk progressors showed significant differences in Prevotellaceae abundance compared with non-progressors, contingent on intrinsic RA risk factors and time to progression
Observational data: associations, not effects.
Further findings
Gut microbiome stability, longitudinal sampling (15 months, five timepoints) · 10 months before RA onset
- Gut microbiome instability in progressors 10 months before RA onset, absent in non-progressors
- 19 participants (5 progressed to RA)
Functional changes during arthritis development
- Structural gut microbiome changes associated with increased amino acid metabolism
Original publication
Dynamics of the gut microbiome in individuals at risk of rheumatoid arthritis: a cross-sectional and longitudinal observational study. Ann Rheum Dis. Published 8 November 2024. doi:10.
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