Lupus & antiphospholipid syndrome
Physical activity in relation to the risk of systemic lupus erythematosus: a prospective study including 401 745 individuals
Authors' conclusion
Participants with moderate or high PA levels had a lower risk of incident SLE than those with low PA levels, independent of sociodemographic and lifestyle factors and environmental triggers.
Study context
- Population
- UK Biobank participants (enrolled 2006–2010) with physical activity (PA) data and no SLE at baseline222 incident SLE
- Participants
- 401,745 participants
- Exposure
- Moderate or high vs low physical activity level
- Outcome
- Occurrence of SLE
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
Incident SLE · median follow-up 12.46 years
Risk reduction
40%
95% CI 0.43–0.85P = 0.004
Moderate PA
Risk reduction
31%
95% CI 0.49–0.97P = 0.033
High PA
- Incidence across PA levels, log-rank test
- P = 0.010
Observational data: associations, not effects.
Further findings
Incident SLE by age at onset (subgroups)
- Results varied by age and sex
- High PA more effective at preventing early-onset (<50 years old) SLE
- Moderate PA showed more significant benefits at preventing late-onset (≥50 years old) SLE
Original publication
Physical activity in relation to the risk of systemic lupus erythematosus: a prospective study including 401 745 individuals. Rheumatology (Oxford). Published 8 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →