Lupus & antiphospholipid syndrome
Apolipoprotein L1 (APOL1) and the risk of adverse renal outcomes in patients of African ancestry with systemic lupus erythematosus
Authors' conclusion
The higher prevalence of renal and hypertensive disorders in SLE patients of AA compared to those of EA is not fully explained by the presence of APOL1 high risk variants.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE) of European and African ancestry in a genetic biobank linked to de-identified electronic health records
- Participants
- 784 patients
- Exposure
- SLE patients of African ancestry vs European ancestry, including and excluding APOL1 high-risk genotypes
- African ancestry (AA)n = 195
- AA with APOL1 HRn = 27
- Outcome
- Prevalence of renal and hypertensive-related disorders by ancestry, including and excluding patients with APOL1 HR genotype
Methodological detailsgenetic biobank linked to de-identified electronic health records, phenome-wide association approach, logistic regression
- Genetic biobank linked to de-identified electronic health records
- Phenome-wide association approach
- Logistic regression
Main finding
As reported in the abstract
- Eighteen renal and hypertensive-related phenotypes were more common in AA than European ancestry (EA) patients
- 18
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| LN-related ESRD (sensitivity analysis)AA vs EA · more prevalent in AA · sensitivity analysis | P < 0.05 |
| LN-related ESRD (sensitivity analysis)AA with APOL1 HR vs AA without APOL1 HR · more prevalent with APOL1 HR genotype · sensitivity analysis | P < 0.05 |
Original publication
APOL1 and the risk of adverse renal outcomes in patients of African ancestry with systemic lupus erythematosus. Lupus. Published 27 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →