Lupus & antiphospholipid syndrome
Role of Platelet‐Bound C4d (Product C4d (PC4d)) in Predicting Risk of Future Thrombotic Events in Systemic Lupus Erythematosus
Authors' conclusion
A PC4d level of >13 MFI predicted future arterial thrombosis and was associated with all thrombosis.
Study context
- Population
- Patients with systemic lupus erythematosus (SLE); PC4d measured by flow cytometry, thromboses confirmed by electronic medical record review19 events in 15 subjects
- Participants
- 418 patients
- Comparison
- PC4d >13 mean fluorescence intensity (MFI) vs PC4d ≤13 MFI
- Outcome
- Future thrombosis events (arterial thrombosis)
- Follow-up
- 3 years post-PC4d level measurement
Performance
As reported in the abstract
Future arterial thrombosis · 3 years
PC4d ≤13 MFI
99%
95% CI 97–100%
NPV
Each group vs PC4d ≤13 MFIEstimate (95% CI)P value
PC4d >13 MFI
HR 4.34(1.03–18.3)
P = 0.046PC4d >13 MFI
diagnostic OR 4.30(1.19–15.54)
Further findings
| Outcome | PC4d ≤13 MFI | Estimate | P value | |
|---|---|---|---|---|
| Future total thrombosis (arterial and venous) · 3 yearsDid not reach statistical significance | diagnostic OR 2.50 (95% CI 0.88–7.06) | P = 0.08 | ||
| NPV | 97% (95% CI 95-99%) | |||
| All thrombosis (n = 70 historic and future arterial and venous events, 5 years pre- to 3 years post-measurement) | OR 2.45 (95% CI 1.37–4.32) | P = 0.0016 | ||
| 0.10.31310Ratio (log scale) |
Original publication
Role of Platelet‐Bound C4d (PC4d) in Predicting Risk of Future Thrombotic Events in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken). Published 27 April 2023. doi:10.
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