Sjögren's disease & overlap diseases
Phosphorylated signal transducer and activator of transcription proteins 1 in salivary glandular tissue: an important histological marker for diagnosis of primary Sjögren’s syndrome
Authors' conclusion
The IFN pathway is the key pathogenic pathway in SjS. p-STAT1 may serve as an important biomarker, in addition to lymphocytic infiltration, to diagnose SjS. Particularly in SG samples with negative lymphatic foci, p-STAT1 confers pathological diagnostic value.
Study context
- Population
- Patients with Sjögren's syndrome (SjS) and non-SjS controls; Salivary gland (SG) tissue
- Comparison
- p-STAT1 immunohistochemistry vs Focus Score in salivary gland tissue for diagnosis of pSS
- Outcome
- Diagnostic value of p-STAT1 for SjS
Methodological detailscase-control, bioinformatics transcriptome analysis, immunohistochemical analysis
- Case-control
- Bioinformatics transcriptome analysis
- Immunohistochemical analysis
Performance
As reported in the abstract
Diagnostic performance for SjS
| Test or model | AUC | Youden (Jorden) index |
|---|---|---|
| p-STAT1 | 0.990 (95% CI 0.969 to 1.000) | 0.968 (95% CI 0.586 to 0.999) |
p-STAT1
AUC0.990 (95% CI 0.969 to 1.000)
Youden (Jorden) index0.968 (95% CI 0.586 to 0.999)
- p-STAT1 vs Focus Score: P < 0.05 — significant difference in both accuracy and sensitivity
Further findings
| Outcome | P value |
|---|---|
| Integrated optical density of p-STAT1 expressionSjS vs Controls · significant difference | P < 0.05 |
| Integrated optical density of p-STAT1 expressionSjS lymphatic foci-negative vs Controls · significant difference | P < 0.05 |
Transcriptome pathway analysis
- Interferon (IFN)-related pathways aberrantly activated in SjS
Original publication
Phosphorylated signal transducer and activator of transcription proteins 1 in salivary glandular tissue: an important histological marker for diagnosis of primary Sjögren’s syndrome. RMD Open. Published 27 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →