Sjögren's disease & overlap diseases
Secretagogue effect of PDE4 inhibitor apremilast on human salivary gland organoids obtained from primary Sjögren's syndrome patients
Authors' conclusion
Our data highlighted that differentiated cells and vital functional organoids that recapitulate the development of original salivary glands can be obtained from pSS epithelium. For the first time, the direct stimulating effect of PDE4 inhibitor apremilast on pSS human salivary gland organoids is reported
Study context
- Population
- Salivary gland tissues (labial or parotid biopsy) from primary Sjögren's syndrome (pSS) patients
- Participants
- 5 participants
- Outcome
- Morphological and functional features of pSS salivary gland organoids after forskolin and apremilast
Methodological detailsin vitro organoid culture
- In vitro organoid culture
Main finding
As reported in the abstract
- Apremilast induced organoid proliferation (cases)
- 3
Original publication
Secretagogue effect of PDE4 inhibitor apremilast on human salivary gland organoids obtained from primary Sjögren's syndrome patients. Clin Exp Rheumatol. Published 23 December 2023. doi:10.
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