Parental autoimmunity and offspring risks of rheumatic diseases: a nationwide population-based study
Authors' conclusion
This study demonstrated broadly how autoimmune diseases pass from parents to infants of both genders and separately quantified the maternal and paternal contributions to disease.
Study context
- Population
- Offspring in the Maternal and Child Health Database and Taiwan National Health Insurance Research Data (NHIRD), 2004 to 2019
- Exposure
- Offspring of a father or mother with an autoimmune disease vs offspring with no parental autoimmune diseases
- Outcome
- Presence of an autoimmune disease in the offspring
Methodological detailsnationwide population-based, inverse probability of treatment-weighted Cox models
- Nationwide population-based
- Inverse probability of treatment-weighted Cox models
Main finding
As reported in the abstract
Autoimmune disease in offspring
Paternal autoimmunity vs no parental autoimmunity: risk of autoimmune disease
1.22 times
Maternal autoimmunity vs no parental autoimmunity: risk of autoimmune disease
1.38 times
Both parents: risk of autoimmune disease
1.39-fold
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| SLE in offspring, maternal autoimmunityMaternal autoimmunityvs No parental autoimmunity | 5.46 (5.28–5.66) | |
| JIA in offspring, paternal autoimmunityPaternal autoimmunityvs No parental autoimmunity | 1.76 (1.71–1.81) | |
| Type 1 diabetes mellitus in offspring, paternal autoimmunityPaternal autoimmunityvs No parental autoimmunity | 1.59 (1.39–1.81) | |
| SLE in boys (subgroup), maternal autoimmunityMaternal autoimmunityvs No parental autoimmunity | 8.55 (8.10–9.02) | |
| Inflammatory myopathy in boys (subgroup), maternal autoimmunityMaternal autoimmunityvs No parental autoimmunity | 2.08 (1.72–2.51) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
Maternal contribution by preterm vs full-term birth (subgroup)
- The maternal contribution effect was stronger for preterm births than for full-term births
Original publication
Parental autoimmunity and offspring risks of rheumatic diseases: a nationwide population-based study. Rheumatology (Oxford). Published 25 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →