Offspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review
Authors' conclusion
Use of some antirheumatic therapies during pregnancy may not be associated with adverse offspring neurodevelopmental outcomes.
Study context
- Population
- Offspring born to parents with chronic inflammatory arthritis who took antirheumatic therapies during conception or pregnancy6 studies
- Comparison
- Antirheumatic therapies during conception or pregnancy in parents with chronic inflammatory arthritis
- Outcome
- Adverse offspring neurodevelopmental outcomes
Methodological detailsprotocol and search strategy designed a priori, PRISMA guidelines, critical appraisal of study quality, Search of Cochrane Library, Embase, Google Scholar, Medline and Web of Science in January 2023; independent reviewers extracted data with a standard abstraction tool
- Protocol and search strategy designed a priori
- PRISMA guidelines
- Critical appraisal of study quality
- Search of Cochrane Library, Embase, Google Scholar, Medline and Web of Science in January 2023; independent reviewers extracted data with a standard abstraction tool
Main finding
As reported in the abstract
- NSAIDs, TNFi and MTX exposure during early first trimester did not seem to increase risk of adverse offspring neurodevelopmental outcomes
- Corticosteroid use during pregnancy seemed to pose an increased risk of attention deficit hyperactive disorders in offspring
Original publication
Offspring neurodevelopmental outcomes born to parents with chronic inflammatory arthritis using antirheumatic therapies: A scoping review. Semin Arthritis Rheum. Published 2 June 2023. doi:10.
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