Maternal systemic autoimmune rheumatic diseases and childhood mental disorders: a nationwide cohort study
Main finding · Childhood MDsResult — go to the resultHazard ratio 1.30 95% CI 1.19–1.41Authors' conclusion
In this nationwide, population-based study from an Asian population, maternal SARDs were associated with higher risks of childhood MDs.
Study context
- Population
- Maternal-child dyads in the Taiwan Maternal and Child Health Database, 2004–2015
- Participants
- 1,949,968 maternal-child dyads
- Exposure
- Offspring of mothers with systemic autoimmune rheumatic diseases (SARDs) vs offspring of mothers without SARDs
- Outcome
- Childhood mental disorders (relevant diagnostic code in nationwide health insurance claims)
- Follow-up
- Mean 11.7 years
Methodological detailsnationwide, population-based, Cox proportional hazard models
- Nationwide
- Population-based
- Cox proportional hazard models
Main finding
Childhood mental disorders (MDs)
Hazard ratio
1.30
95% CI 1.19–1.41
Events by group
SARDsvs Without SARDs
HR 1.30 (95% CI 1.19–1.41)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Childhood MDs by maternal SARD typeSLEvs Without SARDs | 1.26 (1.13–1.41) | |
| Childhood MDs by maternal SARD typePrimary Sjogren's syndromevs Without SARDs | 1.59 (1.29–1.97) | |
| Childhood MDs by maternal SARD typeIIMvs Without SARDs | 1.73 (1.06–2.83) | |
| Childhood MDs by maternal SARD typeSScvs Without SARDs | 1.94 (1.15–3.28) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Maternal systemic autoimmune rheumatic diseases and childhood mental disorders: a nationwide cohort study. Lupus Sci Med. Published 14 August 2026. doi:10.
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