Incidence and risk factors of mental illnesses among patients with systemic autoimmune rheumatic diseases: an 18-year population-based study
Authors' conclusion
This population-based cohort study revealed that patients diagnosed with SLE, SS, and DM had significantly higher risks of developing mental illness when compared with patients with RA.
Study context
- Population
- Patients certified as having a catastrophic illness for systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc), dermatomyositis (DM), polymyositis (PM) or Sjögren's syndrome (SS), Taiwan National Health Insurance Research Database (NHIRD), 2002–2020 (mean age 47.4 years; 76.4% female)
- Participants
- 28,588 patients
- Exposure
- SLE, SSc, DM, PM or SS vs RA
- Outcome
- Incident mental illness
Methodological detailsnationwide, population-based, claims data (Taiwan NHIRD), multivariable Cox regression
- Nationwide
- Population-based
- Claims data (Taiwan NHIRD)
- Multivariable Cox regression
Main finding
As reported in the abstract
Mental illness
Each group vs RAAdjusted hazard ratio (95% CI)
SLE
1.20(1.10–1.32)
SS
1.29(1.19–1.39)
DM
1.28(1.04–1.32)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Antidepressant useSLEvs RA | 1.32 (1.21–1.44) | |
| Antidepressant useSScvs RA | 1.20 (1.02–1.41) | |
| Antidepressant useSSvs RA | 1.17 (1.08–1.26) | |
| Antidepressant useDMvs RA | 1.73 (1.44–2.07) | |
| Antidepressant usePMvs RA | 1.64 (1.32–2.03) | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Incidence and risk factors of mental illnesses among patients with systemic autoimmune rheumatic diseases: an 18-year population-based study. Rheumatology (Oxford). Published 5 April 2024. doi:10.
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