Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study
Authors' conclusion
Rheumatic diseases have a broad impact on reproductive health, with effects comparable with that of several other IMDs. Of the rheumatic diseases, SLE and SS conferred the largest risk increases on perinatal adverse event outcomes.
Study context
- Population
- Finnish citizens born 1964–1984 with any of 19 immune-mediated diseases (IMDs) diagnosed before age 30 (women) or 35 (men), and matched controls
- Exposure
- Individuals with any of 19 IMDs vs matched controls
- Outcome
- Reproductive health measures: reproductive success and, for women, ever having adverse maternal and perinatal outcomes
Methodological detailsmatched (1:20) by birth year, sex and education
- Matched (1:20) by birth year, sex and education
Main finding
As reported in the abstract
Reproductive success
- Several rheumatic diseases, particularly SLE, JIA and seropositive RA, associated with higher rates of childlessness and fewer children
Observational data: associations, not effects.
Further findings
Adverse maternal and perinatal outcomes (pre-eclampsia, SGA newborns, preterm delivery, non-elective Caesarean section, neonatal intensive care)
- Most rheumatic diseases: moderate risk increases for diverse adverse pregnancy outcomes, similar in IBD, celiac disease, asthma, ITP and psoriasis
- 1.1-1.5-fold
- Risks increased in many IMDs
- SLE, SS, type 1 diabetes and Addison's disease: >2-fold risks for some of these outcomes
Original publication
Patterns of reproductive health in inflammatory rheumatic diseases and other immune-mediated diseases: a nationwide registry study. Rheumatology (Oxford). Published 20 March 2024. doi:10.
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