Immune-mediated diseases and risk of incident cardiovascular diseases: a prospective cohort study
Main finding · Total CVDResult — go to the resultHazard ratio 1.57 95% CI 1.52–1.61Authors' conclusion
Total and individual IMDs were associated with an increased risk of overall CVDs.
Study context
- Population
- UK Biobank participants with baseline assessment at 2006–10 (55.6% women; mean age 55.9 years)median follow-up 12.1 years
- Participants
- 414,495 participants
- Exposure
- Participants with immune-mediated diseases (IMDs) vs without IMDs
- IMDsn = 21,784
- Outcome
- Incident CVD
Methodological detailsUK Biobank, Cox proportional hazard models, multivariable adjustment
- UK Biobank
- Cox proportional hazard models
- Multivariable adjustment
Main finding
Total CVD · median follow-up of 12.1 years
Hazard ratio
1.57
95% CI 1.52–1.61
Events by group
IMDsvs Without IMDs
HR 1.57 (95% CI 1.52–1.61)
As reported in the abstract
Observational data: associations, not effects.
Further findings
Cardiovascular disease (CVD) by individual IMD (20 IMDs)
| HR (CI) | ||
|---|---|---|
| Celiac diseaseLowest HR | 1.34 (1.16–1.54) | |
| SLEHighest HR | 2.75 (2.10–3.61) | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | HR (CI) | |
|---|---|---|
| Individual CVD events, any IMD exposureIMDsvs Without IMDsCerebral hemorrhage (lowest) | 1.34 (1.14–1.58) | |
| Individual CVD events, any IMD exposureIMDsvs Without IMDsPericardium diseases (highest) | 1.80 (1.54–2.11) | |
| 0.512Hazard ratio (log scale) |
- CVD by individual IMD (20 IMDs) — 16 of 20 IMDs significantly associated with CVD
- all P < 0.0025 after Bonferroni correction
Individual CVD events, any IMD exposure
- Higher risk of all individual CVD events
Total CVD by IMD duration
- IMD duration <5 years: increased risk
- 55%
- IMD duration 5-10 years: increased risk
- 59%
- IMD duration >10 years: increased risk
- 56%
Original publication
Immune-mediated diseases and risk of incident cardiovascular diseases: a prospective cohort study. Rheumatology (Oxford). Published 1 June 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →