COVID-19 prognosis in systemic lupus erythematosus compared with rheumatoid arthritis and spondyloarthritis: results from the CONTROL-19 Study by the Italian Society for Rheumatology
Authors' conclusion
Our data suggest that patients with SLE and RA do not show a different COVID-19 outcome, while patients with SPA have a more favourable disease course compared with those with SLE.
Study context
- Population
- Rheumatic patients affected by COVID-19 before vaccination, national CONTROL-19 Database (Italy)
- Participants
- 103 / 524 / 486
- Exposure
- SLE vs rheumatoid arthritis (RA) vs SpA in patients with COVID-19 before vaccination
- SLEn = 103reference
- RAn = 524
- Spondyloarthritis (SPA)n = 486
- Outcome
- Hospitalisation with death or mechanical ventilation
Methodological detailsobservational, national registry (CONTROL-19 Database), univariable and multivariable logistic regression
- Observational
- National registry (CONTROL-19 Database)
- Univariable and multivariable logistic regression
Main finding
As reported in the abstract
Hospitalisation with death or mechanical ventilation (prevalence)
Observational data: associations, not effects.
Further findings
Factors associated with severe outcomes in SLE (subgroup)
| OR (CI) | P value | ||
|---|---|---|---|
| Age >65 years | 17.3 (5.51–63.16) | P < 0.001 | |
| Hypertension | 6.2 (2.37–17.04) | P < 0.001 | |
| Prednisone use | 3.8 (1.43–11.39) | P = 0.01 | |
| HCQ useProtective | 0.3 (0.14–0.91) | P = 0.03 | |
| 0.050.21520Odds ratio (log scale) |
Original publication
COVID-19 prognosis in systemic lupus erythematosus compared with rheumatoid arthritis and spondyloarthritis: results from the CONTROL-19 Study by the Italian Society for Rheumatology. Lupus Sci Med. Published 17 October 2023. doi:10.
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