Across rheumatic diseases

Vaccination coverage of influenza and pneumococcal vaccines in patients with rheumatic diseases: a systematic review and meta-analysis

Rheumatology (Oxford)Published Systematic review and meta-analysis

Authors' conclusion

Influenza and pneumococcal vaccine coverage was still suboptimal in patients with rheumatic diseases.

Study context

Population
Patients with rheumatic diseases; studies from PubMed, Embase, Web of Science and Scopus51 studies
Comparison
RA vs SLE vs SpA vs PsA
Outcome
Coverage of influenza and pneumococcal vaccines
Methodological detailssensitivity analyses, subgroup analyses, meta-regression
  • Sensitivity analyses
  • Subgroup analyses
  • Meta-regression

Pooled result

As reported in the abstract

Pooled influenza vaccination rate

Further pooled results

Pooled pneumococcal vaccination rate

Characteristics of vaccinated vs unvaccinated RA patients

Vaccinated RA patients associated with older age and increased prevalence of comorbidities

Sources of heterogeneity

Geographical location and use of DMARDs were two significant factors affecting heterogeneity

Vaccine education and reasons for non-vaccination

Larger proportion received vaccine education from rheumatologists rather than general practitioners
Two major reasons for non-vaccination: 'lack of awareness' and 'not offered by doctors'

Original publication

Vaccination coverage of influenza and pneumococcal vaccines in patients with rheumatic diseases: a systematic review and meta-analysis. Rheumatology (Oxford). Published 3 July 2026. doi:10.1093/rheumatology/keag352

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