Lupus & antiphospholipid syndrome
Paranasal sinus occupancy assessed from magnetic resonance images—associations with clinical indicators in patients with systemic lupus erythematosus
Authors' conclusion
In patients with SLE, MRI computational assessment of sinuses opaqueness and LM scores modified at a 50% cut-off may be useful tools in understanding the relationships among paranasal sinus occupancy, disease activity and SVD markers.
Study context
- Population
- Patients with SLE with paranasal sinus MRI
- Participants
- 51 patients
- Outcome
- Paranasal sinus opaqueness on MRI and its association with disease activity, inflammation, endothelial dysfunction and small vessel disease (SVD) markers
Methodological detailsvisual scoring and expert-delineated computational volumes, adjusted for age and sex-at-birth
- Visual scoring and expert-delineated computational volumes
- Adjusted for age and sex-at-birth
Main finding
As reported in the abstract
- Average paranasal sinus volume occupation, mainly maxillary and ethmoid sinuses
- 4.55 (6.47%)
- Paranasal sinus volume occupation, median (IQR)
- 0.67 (0.25-2.65) ml
- Correlation with Lund-Mackay (LM) scores modified at 50% opaqueness cut-off, maxillary (Spearman's ρ)
- 0.71, P < 0.001
- Correlation with modified LM scores, ethmoids (Spearman's ρ)
- 0.618, P < 0.001
- Modified LM scores vs small vessel disease (SVD) score 0
- B = 5.078, s.e. = 1.69, P = 0.0026
- Modified LM scores vs SVD score 2
- B = −0.066, s.e. = 0.023, P = 0.0045
- Modified LM scores vs anti-dsDNA
- B = 4.59, s.e. = 2.22, P = 0.045
- Modified LM scores vs SLEDAI 3-7
- 2.86 < B < 4.30; 1.38 < s.e. < 1.63; 0.0083 ≤ P ≤ 0.0375
Observational data: associations, not effects.
Original publication
Paranasal sinus occupancy assessed from magnetic resonance images—associations with clinical indicators in patients with systemic lupus erythematosus. Rheumatology (Oxford). Published 22 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →